Health & Nutrition by Michael R. Eades, M.D.

The May 2008 issue of Obesity Reviews, the journal of the International Association for the Study of Obesity, contained a review written by George Bray, M.D. of Gary Taubes’ book Good Calories, Bad Calories (GCBC). Gary Taubes has written a rebuttal that will appear in this same journal. Before we get to Gary’s response, I would like to spend a little time on Bray’s review, which I found interesting and troubling on a number of fronts.

Most reviews of books in academic journals are of academic books and are, at most, a page and a half, maybe two pages, long. The Bray review of GCBC was 13 pages long, including two plus pages of citations. And this for what is basically a popular book written for a general audience, not an academic tome. In all the reading I do of the medical literature, I’ve never seen a book review come even close to this in terms of length and comprehensiveness. Obviously Taubes’ work struck a chord.

George Bray, M.D. is probably the most renown figure in the field of obesity research today. He is the Boyd Professor at the Pennington Biomedical Research Center (and former executive director) in Baton Rouge, LA; he holds numerous other professorships at various academic institutions; he has held leadership positions in virtually every academic obesity organization in existence; he has authored or co-authored more than 500 scientific papers; he has written at least a dozen books and authored chapters in many more; and he figures prominently in the recent history of how the academic ideas of the causes and cures of obesity are what they are today. It speaks volumes that someone of Dr. Bray’s academic stature would be tapped to write a review (a review, in fact, that is longer than most scientific papers) of a popular book. GCBC has gotten the attention of the academic community.

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Moonrise, Jackson Hole (click to enlarge) photo by Daniel Eades

A study published in the current edition of the New England Journal of Medicine demonstrates once again that the low-carbohydrate diet is better than the low-fat diet in bringing about both weight loss and an improvement in lipid profiles. This study, as published, is not without its flaws, which we will get to in a due course. What I find amazing - or maybe I don’t - has been the press reaction.

First came the television reports (here, here and here), all of which reported the study as the atkins diet triumphing over the low-fat diet and the beloved Mediterranean diet. TV was made for sound bites and sensationalism, so this report fits right in. Although numerous studies have shown the same superiority of the low-carb diet, the TV media seems to treat these studies in one of two ways: it ignores them or it treats them as a man-bites-dog kind of story. The print media has had a little time to reflect on the situation and is reporting the study in a different way.

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We’ve finally got the cover art for the new book, which is now up on Amazon for pre-order! It will not hurt our feelings a bit if you all order copies for your several thousand closest friends.

We’re in Wyoming right now, in Jackson Hole to be exact. We came out on a quick trip for a meeting and a little R & R while we’re here. Since we kind of left on short notice and aren’t really going to stay long (plus I didn’t know exactly what our accommodations would be), I didn’t bring my normal stack of medical papers. Hence, I’ll be blogging on some not so scientific stuff for the next couple of posts.

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Aubrey de Grey (here, here and here) is an iconoclastic anti-aging researcher living in Cambridge, UK who approaches the science of anti-aging medicine from an engineering perspective (requires free registration). He lectures extensively and constantly pushes the boundaries of anti-aging research. He isn’t trained in biology or medicine, but as an engineer. His extensive knowledge of medicine and the biological sciences is pretty much self taught. He doesn’t subscribe to any particular medical or scientific ideology, i.e., alternative medicine verses mainstream medicine, or any specific dietary practices other than the idea that caloric restriction has been shown in animal studies to prolong life. But Dr. de Grey isn’t interested in the mere 20-30 percent increase in lifespan brought about by caloric restriction; he’s more interested in increasing lifespan 100 to 200 years or more. Which he believes can be done if we look at forestalling aging from an engineering point of view.

He has written (co-written, actually) a book titled, appropriately enough, Ending Aging describing his theories of aging and discussing the problems that must be overcome to undo the forces of our own biochemistry and physiology that grind us down over time. I read the book when it first came out and found it fascinating. I wouldn’t think it’s a particularly an easy read for one not scientifically inclined. If you thought Gary Taubes’ book was difficult, I wouldn’t recommend this one. If you do get it and are prepared to spend some time really digging in, you will come away rewarded, if not in understanding (which you will certainly get) at least in the knowledge that there are many extremely clever people working to keep us living longer. If you just want to read a little of the book, I recommend Chapter 5, Meltdown of the Cellular Power Plants, which is a virtuoso piece of scientific reasoning. Dr. de Grey published his theory of mitochondrial survival of the slowest, the subject of this chapter, a few years back, and I thought it a brilliant piece of scientific detective work.

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